Trends in lifetime risk and years of life lost due to diabetes in the USA, 19852011: a modelling study
Through this intracellular coupling, astrocytes supply neurons with cysteine or cysteinyl-glycine derived from exported GSH, thereby supporting neuronal GSH synthesis and resistance to damaging, redox-driven processes (Takahashi and Mashima, 2022)
For instance, exosomes secreted by adipose tissue macrophages caused ferroptosis by targeting SLC7A11 to inhibit GSH synthesis in the heart [249]
Two recent studies provide evidence that glutathione has a crucial role in the isomerization of nonnative disulphide bonds
Mice with adipose tissue-specific Bcat2 knockout showed resistance to high-fat diet-induced obesity, exhibiting enhanced browning of white adipose tissue and increased thermogenic capacity (111)
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